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KMID : 0383820100690060474
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Tuberculosis and Respiratory Diseases
2010 Volume.69 No. 6 p.474 ~ p.479
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Levofloxacin and Torsades de Pointes
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Kwon Se-Ah
Kim Cheol-Hong
Song Won-Jun
Koo Ja-Kyung
Lee Soon-Jae
Park Ji-Young
Hyun In-Gyu
Ko Jang-Hyu
Kim Hyun-Soo
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Abstract
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Torsades de pointes associated with a prolonged QT interval is a life-threatening arrhythmia, which may be induced by any of the following: drugs, electrolyte imbalances, severe bradycardia and intracranial hemorrhage. Torsades de pointes is characterized by beat-to-beat variations in the QRS complexes in any ECG leads with rates of 200∼250 per minute. Fluoroquinolones are widely used and well tolerated antibacterial agents. However, prolongation of the QT interval leads rarely to Torsades de pointes as a significant adverse effect. So, it should be used with caution in high-risk patients for developing Torsades de pointes. We report one case of 67-year old man with contact burns who experienced Torsades de pointes, which probably resulted from the use of levofloxacin, and no further episode occurred after its withdrawal.
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KEYWORD
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levofloxacin, Torsades de Pointes
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